Y-chromosome haplogroups and risk of cardiovascular diseases (literature review)

• Chechulova A.V.
• Soroka V.V.
• Gorbunova A.V.

Abstract

This article is a review of the most relevant information concerning the nature of polygenic diseases, considering the mechanisms of pathogenesis of cardiovascular diseases from the point of view of their regulation by genes located on the Y-chromosome, with a detailed analysis of the literature data dedicated to studying the association of polygenic diseases with the Y-chromosome and Y-DNA haplogroups.

Various countries over the past decades, based on which a conclusion was drawn on ­possible involvement of the Y-chromosome in regulation of the function of the cardiovascular system, which may serve as one of the strongest genetic markers of cardiovascular diseases.

Keywords:haplogroups; ethnogenetics; Y-chromosome; polygenic diseases; venous thromboses; Y-DNA; genetic variability; risk factors

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