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Pharmacological correction of endothelial dysfunction in patients with atherosclerotic lesions of peripheral arteries and diabetes mellitus (literature review)

Abstract

The incidence of diabetes mellitus is steadily increasing worldwide. The most frequent and severe complications of diabetes mellitus are micro- and macroangiopathies accompanied by endothelial dysfunction and leading to early disability and premature mortality. The problem of enhancing the efficacy of pharmacological correction of endothelial dysfunction in operated patients with critical lower limb ischemia on the background of diabetes mellitus remains currently important because of unsatisfactory results of standard pathogenetic therapy prescribed to patients in the pre- and postoperative periods. Discussed in this review are the mechanisms of development of endothelial dysfunction in patients with diabetes mellitus and obliterating atherosclerosis of the arteries of the lower extremities, methods for determining and identifying endotheliopathy, as well as possible pharmacological modalities of correcting endothelial dysfunction.

Funding. The review was prepared with the support of the grant No. 21-15-00192 dated 19.04.2021.

Conflict of interest. The authors declare no conflicts of interest.

Authors’ contribution. Study conception and design – Frolov D.V., Dyachkova Yu.A.; data collection and handling – Dyachkova Yu.A., Obukhov A.D.; draft manuscript preparation – Dyachkova Yu.A.; manuscript revision – Tyurenkov I.N., Frolov D.V.

For citation: Tyurenkov I.N., Frolov D.V., Dyachkova Yu.A., Obukhov A.D. Pharmacological correction of endothelial dysfunction in patients with atherosclerotic lesions of peripheral arteries and diabetes mellitus (literature review). Angiology and Vascular Surgery. Journal named after Academician A.V. Pokrovsky. 2024; 30 (1): 18–25. DOI: https://doi.org/10.33029/1027-6661-2024-30-1-18-25

Keywords:endothelial dysfunction; diabetes mellitus; critical lower limb ischemia; Rivaroxaban

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Akchurin Renat Suleymanovich

Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Deputy General Director for Surgery, Head of the Department of Cardiovascular Surgery, National Medical Research Center for Cardiology named after Academician E.I. Chazov, President of the Russian Society of Angiologists and Vascular Surgeons

In accordance with the decision of the Presidium of the Russian Society of Angiologists and Vascular Surgeons, the journal "Angiology and Vascular Surgery" will be named after Academician A.V. Pokrovsky starting from No. 2/2022.