Use of glue adhesives for obliteration of major varicose veins (multicenter comparative study)


The purpose of this study was a comparative analysis of the immediate and short-term (up to 1 year) results of clinical use of cyanoacrylate compound proposed by «Medtronic» in the «VenaSeal» system and the domestic adhesive «Sulfacrylate» in the «VenoGlue» Russian system for obliteration of varicose veins. A fundamental difference of the domestic cyanoacrylate compound from all foreign analogues is that it is synthesized on the basis of ethyl ether of α-cyanoacrylic acid, while all foreign analogues are synthesized on the basis of butyl ether of α-cyanoacrylic acid.

Cyanoacrylate obliteration of varicose veins was performed in 73 patients using a foreign compound and in 75 patients using a domestic substance. All patients had a C2-C3 clinical class according to CEAP. In the postoperative period, we assessed severity of phlebitis and pain response according to a visual analogue scale (VAS), changes in the quality of life according to CIVIQ-2, and the degree of occlusion of the segment of the main saphenous vein exposed to the adhesive substance according to the results of ultrasound duplex angioscanning.

The conducted studies with a follow-up period of up to 1 year allow us to conclude about safety and high efficiency of using the domestic adhesive compound "Sulfacrylate" for endovasal obliteration of varicose veins in humans. By the effect on quality of life, severity and duration of inflammatory reaction, degree of obliteration of the target vein, the Russian glue adhesive proved not inferior to a foreign analogue used in the VenaSeal system. Undeniable advantages of using domestic cyanoacrylate adhesive are its staged biodegradation with complete connective tissue obliteration of the lumen of the veins and low cost of manipulation.

Funding. The study had no sponsor support.

Conflict of interest. The authors declare no conflict of interest.

For citation: Shaydakov E.V., SannikovA.B., Belentsov S.M. Use of glue adhesives for obliteration of major varicose veins (multicenter comparative study)Angiology and Vascular Surgery. 2022; 28 (1): 41–9. DOI: (in Russian)

Keywords:cyanoacrylate obliteration; non-thermal ablation; non-tumescent obliteration; endovenous ablation using adhesive; varicose veins; cyanoacrylate medical adhesive “Sulfacrylate”

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Akchurin Renat Suleymanovich
Doctor of Medical Sciences, Professor, Academician of the Russian Academy of Sciences, Deputy General Director for Surgery, Head of the Department of Cardiovascular Surgery, National Medical Research Center for Cardiology named after Academician E.I. Chazov, President of the Russian Society of Angiologists and Vascular Surgeons


In accordance with the decision of the Presidium of the Russian Society of Angiologists and Vascular Surgeons, the journal "Angiology and Vascular Surgery" will be named after Academician A.V. Pokrovsky starting from No. 2/2022.

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